As expected, a moderate to strong correlation was found between myocardial fibrosis and NT-ProBNP (r = 0.47, p < 0.001; Fig 2B), and also between LVEF and NT-ProBNP, as a negative correlation (r = 0.69, p < 0.001; Fig 3B). The gene discussed is NPPB; the disease is Myocardial fibrosis.