DENND1A and polycystic ovary syndrome: The first genome-wide association studies (GWAS) and subsequent follow-ups were performed in Han Chinese women, and investigators identified the following PCOS candidate loci: DENND1A, INSR, YAP1, C9orf3, RAB5B, HMGA2, TOX3, SUMO1P1/ZNF217, THADA, FSHR, and LHCGR [12, 13]; DENND1A was validated by another study [14].