These include delamination of epithelial cells and epithelial–mesenchymal transition necessary for non-local epithelial cell migration [142], basement membrane degradation and remodeling by urokinase and matrix metalloproteinase [143], activation of focal adhesion kinase and paxillin causing integrin-dependent migration [48], pre-metastatic niche formation via tumor-derived exosomes [14], tumor lymphangiogenesis [144,145], and hemangiogenesis [146,147]. This evidence concerns the gene PXN and neoplasm.