Butyrate action has also been implicated in the wingless/MMTV integration site (Wnt) pathway, likely mediated by an increased association of the cAMP-response element-binding protein (CREB) binding protein (CREBBP, or CBP) and the histone acetyltransferase p300, thereby encouraging the transcription of Wnt-related proteins involved in apoptosis of colorectal cancer cells [109,110]. The gene discussed is CREBBP; the disease is colorectal cancer.