Suriano G. and colleagues [47] generated transgenic fly lines carrying cDNAs of wild-type human E-cadherin (hEcad) and two missense mutant forms obtained from HDGC patients: hEcad-A634V, which affects the extracellular protein domain, and hEcad-V832M, affecting the intracellular portion. Here, CDH1 is linked to CDH1-related diffuse gastric and lobular breast cancer syndrome.