In this circumstance, loss of NKG2D results in reduced tumor killing, as exemplified by the observation that NKG2D-deficient mice show reduced killing/rejection of B16-MULT1 tumors and YAC-1 cells (Figure 6D, Figure 2—figure supplement 1B) (Jamieson et al., 2002). This evidence concerns the gene KLRK1 and neoplasm.