Our findings are in agreement with Dassano et al. [32] who showed that in breast cancer and HL-60 cells induced to differentiate in neutrophilic lineage, iPA was able to trigger the NRF-mediated oxidative response through the induction of gene encoding detoxifying and anti-oxidant enzymes—such as heme oxygenase-1 gene and glutamate-cysteine ligase (GCLC)—that protect cells against ROS and reactive metabolites. The gene discussed is HMOX1; the disease is breast cancer.