STAT3 and cystic fibrosis: NFκB, MAPK/ERK, and STAT3 pathways plays a central role in the inflammatory signaling cascades leading to cytokine and chemokine production and some studies have demonstrated that NFκB and MAPK/ERK pathways are intrinsically overactivated in various CF cell lines [22, 29, 30]; therefore, to assess whether the effects of iPA could be a result of the modulation of these pathways, CuFi-1 cells were incubated with iPA 2.5 μM and then the main molecular targets of MAPK/ERK, NFκB and STAT3 pathways were analyzed.