To investigate this issue, we analyzed the effect of iPA on IL-8 and RANTES release in CuFi-1 (CFTRΔF508/ΔF508) and NuLi-1 cell lines (CFTR wild type) which are both telomerase-immortalized airway cells, characterized by the ability to constitute a polarized monolayer with a transepithelial activity that mimics the behavior of CF airway epithelial cells in vivo [20]. The gene discussed is CXCL8; the disease is cystic fibrosis.