Interestingly, we found that there is no significant expansion of the levels of tumor-infiltrating APC in CRC patients, but the levels of APC in normal colon tissue are significantly higher than in breast tumor tissue (CRC NT; 1.43 ± 0.72, TT; 2.79 ± 1.58 versus PBC NT; 0.04 ± 0.01, TT; 1.06 ± 0.36, Figure 2, f). This evidence concerns the gene APC and primary biliary cholangitis.