VHL and breast cancer: Similarly, ubiquitin C-terminal hydrolase-L1 was described to abrogate the pVHL-mediated ubiquitination of HIF-1α in mouse models of pulmonary metastasis (57), and c-Myc has been shown to weaken HIF-1α binding to pVHL complex, eventually leading to normoxic HIF-1α stabilization in breast cancer cells (58).