While in patients with poorly differentiated tumors, patients with LCC had significantly higher amount of pDCs (P = 0.036), CD4+ Tm cells (P = 0.012), CD4+ T cells (P = 0.028), Tm cells (P = 0.014) and Treg cells (P = 0.001) than patients with RCC. The gene discussed is CD4; the disease is leukoencephalopathy with calcifications and cysts.