Finally, while attention to date has focused on developing small molecule agonists of Mincle signaling, future efforts should seek to discover small molecule antagonists of Mincle signaling in conditions of sterile inflammation, which could assist in probing the role of Mincle in diseases such as stroke (74), atherosclerosis (22), Gaucher’s disease (26), skin allergies (25), and hepatitis (75). Here, CLEC4E is linked to stroke disorder.