Recently Janzen et al. (2013) found that GLUT3 protein expression is higher in the trophoblast of full-term IUGR placentas than in that of normal placentas but that there are no differences in GLUT1 or GLUT4 expression whereas GLUT1 and GLUT3 expression is increased when human trophoblast cells, primary cells, or cell lines are maintained under hypoxic conditions; this increase is probably mediated by hypoxia-inducible factor 1α (HIF-1α) (Esterman et al., 1997; Hayashi et al., 2004; Baumann et al., 2007). This evidence concerns the gene SLC2A4 and fetal growth restriction.