NFE2L2 and hepatocellular carcinoma: In the present study, we have investigated the effect of CTN on Keap1/Nrf2 pathway and the role of PC in activation of the transcription factor Nrf2 and its target genes NQO1, HO-1, GST in ameliorating CTN-induced toxicity in Human hepatocellular carcinoma (HepG2) cell line.