Moreover, mice that lacked GPC1 exhibited decreased tumor angiogenesis and metastasis following intrapancreatic implantation with either PANC-1 or T3M4 human pancreatic cancer cells and had fewer pulmonary metastases following intravenous injection of murine B16-F10 melanoma cells [74]. This evidence concerns the gene GPC1 and familial pancreatic carcinoma.