GPT and Nephropathy: As expected, the treatment with AaE, artemisinin, or arteannuin B did not result in elevated serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which are indicative of liver damage (Supplementary Fig. S1c), or of blood urea nitrogen (BUN) and creatinine, which are indicative of kidney damage (Supplementary Fig. S1d).