LOXL3 and melanoma: Similarly, LOXL3 transduction in a metastatic melanoma cell line (501MEL) harboring minimal endogenous LOXL3 levels (Fig. 1f and Supplementary Fig. 3a) promoted migration and invasion without affecting cell proliferation (Supplementary Fig. 3b–d), whereas endogenous LOXL3 silencing had analogous effects as previously shown for other melanoma cell lines (Supplementary Fig. 3e–g).