Moreover, LOXL3 silencing was deleterious for primary (A375P and WM98-1) and metastatic melanoma cell lines (SK-MEL-28, SK-MEL-147, and MeWo) corroborating that melanoma cells require LOXL3 expression to survive independently of their mutational status or the disease stage from which they were derived. The gene discussed is LOXL3; the disease is melanoma.