Moreover, LOXL3 silencing was deleterious for primary (A375P and WM98-1) and metastatic melanoma cell lines (SK-MEL-28, SK-MEL-147, and MeWo) corroborating that melanoma cells require LOXL3 expression to survive independently of their mutational status or the disease stage from which they were derived. Here, LOXL3 is linked to metastatic melanoma.