In addition to mutations in the scaffold subunits, B55α (encoded by the PPP2R2A gene) and B55β (encoded by PPP2R2B) subunits are occasionally eliminated by deletion or hypermethylation of the corresponding genes [1, 3, 5] suggesting the relevance of PP2A-B55 activity in preventing breast cancer development. The gene discussed is PPP2R2A; the disease is breast carcinoma.