We also explored a potential contribution of exportin-1 (XPO1/CRM1) in this process because XPO1 associated with RanBP6 and EGFR in our mass spectrometric analyses (Supplementary Data 5) and CRM1 inhibition had been reported to reduce STAT3 levels in a breast cancer cell line21. The gene discussed is RANBP6; the disease is breast carcinoma.