When cell lines were stratified by PTEN status, the inverse correlation between RANBP6 and EGFR mRNA levels was only present in cancer cell lines without PTEN alteration (Pearson product–moment correlation r = −0.22, p-value = 2e−09) but not in cell lines with PTEN alteration (Pearson product–moment correlation r = −0.066, p-value = 0.43) (Fig. 5e, right panels) (Supplementary Data 6). The gene discussed is PTEN; the disease is cancer.