In contrast, we observed no changes in the subcellular localization of several other cancer-related proteins, including the transcription factors p53 and c-Jun, retinoblastoma-associated protein (RB), p27Kip1, forkhead box protein O3 (FOXO3), and survivin (Fig. 3a; Supplementary Fig. 3). This evidence concerns the gene BIRC5 and cancer.