RANBP6 and central nervous system cancer: RanBP6 knockdown decreased survival, with mice injected with the RanBP6 shRNA living an average of 189 days (n = 10) and control mice living 275.5 days (n = 14) (p = 0.047, log-rank test) (Fig. 6g) and promoted the development of higher-grade gliomas (Fig. 6h; Supplementary Fig. 11).