EGFR and neoplasm: In human GBM tumor sections, we observed an inverse correlation between RanBP6 and EGFR protein levels (Supplementary Fig. 8) and RanBP6 knockdown upregulated EGFR expression in the human GBM cell line LN18 (Supplementary Fig. 9), consistent with earlier results in HEK-293T cells and MEFs.