While RanBP6 did not affect a variety of cancer-associated signaling molecules, including other receptor tyrosine kinases (e.g., PDGFRA, PDGFRB, ERBB2, and ERBB3) (Supplementary Fig. 12), we cannot exclude the possibility that the tumor suppressor activity of RanBP6 is mediated by effects that go beyond its effects on EGFR. Here, ERBB3 is linked to cancer.