JNK signaling in adipose tissue has been linked to interleukin 6 (IL-6) expression in experimental models29, and our previous mouse studies suggested a main role for exacerbated IL-6 production in mediating the pathogenic actions of WNT5A in the setting of obesity-induced adipose tissue dysfunction and associated metabolic abnormalities14. The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.