AnxA2 belongs to the calcium- and phospholipid-binding protein family of annexins [6, 7] and is a host cellular marker found aberrantly expressed in various malignant tumors (colon, lung, gastric, oesophageal, and breast) [8–12] including hepatocellular carcinoma (HCC) [13–17]. This evidence concerns the gene ANXA2 and hepatocellular carcinoma.