To explore whether autocrine TGF-β1 signaling plays a role in the mechanism by which LXA4 suppresses the mesenchymal phenotypes in pancreatic cancer cells, anti-TGF-β1 neutralizing antibody and exogenous rhTGF-β1 were used to modulate the concentration of TGF-β1 in the cell culture media. This evidence concerns the gene TGFB1 and pancreatic neoplasm.