CXCL8 and HIV-1 infection: Given that neutrophils are primarily recruited by the proinflammatory chemokine IL-8 and our data indicate that IL-8 secretion by astrocytes is affected by HIV-1 infection and treatment with bryostatin-1 and JQ1, we monitored the possible regulatory effect of the astrocyte secretory activity in response to bryostatin-1 and JQ1 on neutrophil transmigration through an in vitro human BBB experimental model (Fig. 5).