TNF and inflammatory bowel disease: The only significant association between anti-TNFα use and genetic risk variants was found for ATG16L1. While there were no associations between ATG16L1 risk allele carriers and IFX use/response, neither in the entire cohort, nor in CD and UC sub analyses, IBD patients carrying the ATG16L1 SNP were significantly more prone to use ADA (p = 0.004, OR 2.4, CI 1.3–4.4, corrected for age, extra-intestinal manifestations, IBD subtype and multiple testing).