Suggesting that patterns of bone changes in early RA may be similar to the systemic hormonal mediated catabolic (negative) remodeling in bone commonly seen with aging, with the negative imbalance in bone remodeling in RA likely mediated more by proinflammatory cytokines that are known to be osteoclastogenic in nature, such as RANKL and Osteoprotegerin (OPG) [8, 44, 45]. This evidence concerns the gene TNFRSF11B and rheumatoid arthritis.