CDKN2BAS belongs to long noncoding RNA(lncRNA) and affects the surrounding gene expression indirectly play a role in the disease, Bai Y research results show that CDKN2BAS can regulate the expression of CARD8 level, which affects the progress of atherosclerosis, compare the RNA in aneurysm tissue and normal cerebrovascular, hundreds of lncRNA exists differences, we can’t help but question: would CDKN2BAS cause IA formation? The gene discussed is CARD8; the disease is atherosclerosis.