Different from GMP-derived leukemias induced by Setbp1 and BCR/ABL [10], Hoxa9+BCR/ABL and Hoxa10+BCR/ABL leukemias are mostly monoclonal in origin (Supplementary Figure 6), suggesting that additional mutation(s) is likely required for the transformation in both cases. This evidence concerns the gene HOXA10 and leukemia.