Our findings on the capability of Myb to drive CML myeloid blast crisis development and the prevalent overexpression of MYB in CML myeloid blast crisis patients further suggest that inhibition of MYB activity could be an effective strategy for inhibiting the self-renewal of LICs in CML myeloid blast crisis. Here, MYB is linked to chronic myelogenous leukemia, BCR-ABL1 positive.