To gain further insights into the mechanisms inducing GMP self-renewal in CML blast crisis, we tested whether overexpression of Hoxa9 or Hoxa10, both critical targets of Setbp1, is sufficient to confer unlimited self-renewal capability to myeloid progenitors and to induce the development of CML blast crisis. The gene discussed is HOXA10; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.