MKI67 and brain neoplasm: Immunohistochemistry analysis of Ki-67 and pEGFR in brain tumor tissues showed that compared with the negative control group (integrated optical density [IOD] value 1,092.62±480.72), gefitinib and erlotinib inhibited Ki-67 expression (IOD values: 198.55±56.67 and 163.37±139.51, respectively [p<0.05]).