BRCA2 and ovarian cancer: Increases of canonical NHEJ activities, in particular, have been reported to correlate with and contribute to the phenotype of Fanconi Anemia (FA) caused by bi-allelic mutations in a set of DNA repair genes including genes like BRCA2, PALB2 and RAD51C causing breast and/or ovarian cancer susceptibility in heterozygous mutation carriers [13, 14].