For the joint analysis of CRC and advanced adenomas versus all controls, AB vs. CD, MOSGWA selected 14 SNPs, including rs17659990 (P=5.43×10-9, DOCK3) that reached the generally accepted level of genome-wide significance, followed by borderline significant rs7742915 (P=8.52×10-8, BTBD9), rs16944613 (P=1.49×10-7, CRTC3), rs13129679 (P=2.38×10-7, RNF4) and rs12953717 (P=3.00×10-7, SMAD7), a well-known CRC susceptibility variant. The gene discussed is RNF4; the disease is adenoma.