In addition, CD59 is one of the most commonly reported positive markers for adipose-derived stem cells [37] and human mesenchymal stem cells [38]; transferrin receptor is preferentially required and overexpressed by glioblastoma stem-like cells [39]; and profilin is required for germline stem cell maintenance [40] and promotes migration, invasion, and stemness of human colorectal cancer stem cells [41]. This evidence concerns the gene CD59 and colorectal cancer.