Therefore, we analyzed this gene profile (MAP17, HLA-A, HLA-B, HLA-C, BBS10, HERC2 and ADNP) in non-tumoral samples of inflammatory syndromes, using chronic obstructive pulmonary disease (COPD), lung fibrosis and Barrett's esophagus to represent the inflammatory state and using both normal macrophages and epithelia to determine basal levels. Here, HERC2 is linked to esophageal adenocarcinoma.