CD274 and non-small cell lung carcinoma: Recently approved tests for anti-PD-1/PD-L1 therapy in NSCLC include the assessment of PD-L1 expression using immunohistochemistry (IHC) as a companion diagnostic test (22C3 for pembrolizumab) [5, 7] and 2 complementary diagnostic tests (28-8 for nivolumab and SP142 for atezolizumab) [3, 4, 8].