YAP1 and cancer: Studies supporting YAP1 as a tumor suppressor include a) decreased YAP1 expression in several cancer cell lines and tumors; b) suppression of anoikis, increased cell migration and invasion and enhanced xenograft tumor growth and metastasis upon knockdown of YAP1; and c) induction of apoptosis in response to DNA damage by YAP1 in association with p73 [16–22].