Compared with CADM1 rs12286929 G/A heterozygotes with BMI < 24 group, individuals with CADM1 A/A+G/G homozygotes and BMI ≥ 24 showed increased risk of breast cancer (OR = 1.78, 95% CI: 1.32–2.40). Here, CADM1 is linked to breast carcinoma.