Immunohistochemical analysis and ONCOMINE data mining of the present study showed that the expression of PDLIM protein in PCa tissues was abnormally higher than that in normal prostate tissues, and the abnormally increased expression of PDLIM5 was associated with Gleason score, serum PSA level, metastasis and invasion and therefore may prove to be an independent risk factor for BCR in increasing the overall mortality. This evidence concerns the gene KLK3 and posterior cortical atrophy.