Skeletal muscle exerts a key role in regulating whole body glucose homeostasis, which is responsible for 70%–80% of insulin-stimulated glucose uptake, skeletal muscle insulin resistance(IRSM) is not only most likely a major determinant of type 2 diabetes, but also plays a major role in the pathogenesis of abdominal obesity, hypertension, coronary heart disease, atherosclerosis and other cardiovascular disease[2]. The gene discussed is INS; the disease is atherosclerosis.