To test whether MORC2 and its PRD domain affect the ability of breast cancer cells to colonize the lung, MDA-MB-231 cells stably expressing pCDH, Flag-MORC2 WT, and Flag-MORC2 ΔPRD were injected into the tail vein of nude mice and the lung metastasis nudes were examined after 6 weeks of injection. Here, MORC2 is linked to breast carcinoma.