The identified genetic alterations are primarily linked to the Wnt signaling pathway, with a relatively high frequency of CTNNB1 activating mutations [10, 11]; its role was demonstrated after insertion of CTNNB1 mutations in precursor liver cells, resulting in high incidence of hepatocellular carcinomas and hepatoblastomas in mice [12]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.