Among the 765 genes associated with the set of common DMSs, there was an enrichment for Metabolic, Cancer, Insulin, MAPK, Hedgehog and Wnt signaling pathways, as well as Regulation of the actin cytoskeleton, Adherens junction, Glycolysis/Gluconeogenesis and Drug Metabolism (Supplementary Table 3). This evidence concerns the gene INS and cancer.