Our results show that P2X7R (~20-fold) (Figure 1A), its key inflammasome components: caspase-1 (15-fold) (Figure 1B), IL-1β (~45-fold) (Figure 1C), and in addition to (data not shown) IL-18 (~35-fold), IL-33 (~93 folds), TNF-α (~13-fold) and COX-2 (~41-fold) are increased in pancreatic tumors compared to normal pancreas. Here, TNF is linked to pancreatic neoplasm.