NOS2 and pancreatitis: Inflammation can be tumorigenic through multiple molecular mechanisms, including elevated inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-1β, IL-18, and P2X7 receptor (P2X7R), to name a few, and is found particularly in pancreatitis and pancreatic tumors [7–11].