The areas under the receiver operating characteristic curve (AUROC) for diagnosing HCC patients with cirrhosis was 0.754 for AFP, 0.701 for protein induced by vitamin K absence or antagonist-II (PIVKA-II), 0.670 for the Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and 0.773 for combination of the three serum biomarkers [5]. The gene discussed is AFP; the disease is hepatocellular carcinoma.