Mutation of Snail1 at lysine 234 to arginine (K234R) inhibited sumoylation of Snail1, its nuclear translocation, and also the TGFβ-induced migratory and invasive properties in prostate cancer cells (Figure 9), suggesting that sumoylation is important for Snail1 function. This evidence concerns the gene SNAI1 and Familial prostate cancer.