1. The expression of sPD-L1 in advanced NSCLC patients was significantly upregulated compared with the healthy control (p < 0.001);2. The expression of sPD-L1 was significantly correlated with abdominal organ metastasis (p = 0.004);3. A high sPD-L1 expression had a worse prognosis than a low expression in patients (p < 0.001). Here, SPDL1 is linked to non-small cell lung carcinoma.