1.The expression of sPD-L1 in cancer patients was significantly up-regulated compared with health people (p = 0.006);2. The expression of sPD-L1 was significantly correlated with differentiation (p = 0.026) and lymph node metastasis (p = 0.041);3. The adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients (p = 0.028). The gene discussed is SPDL1; the disease is cancer.