Next, we employed module-trait relationship analysis to conduct the association between eight MEs and 13 clinical traits (including race, sex, age, HB subtypes, Cairo classification, tumor stage, CTNNB1, NFE2L2 and TERT mutation status, histological types, prognosis, tumor recurrent status and survival time). The gene discussed is NFE2L2; the disease is Meckel syndrome, type 1.