MKI67 and metastasis: To evaluate whether Jab1/COPS5 in breast cancer was independent predictor of DFS and OS, a multivariate analysis was performed with the following variables: age, histological type, tumor grade, tumor stage, tumor size, lymph node metastasis, Her2 status, ER status, PR status, menopause status, family history of cancer, Ki-67 and Jab1/COPS5.