IFIT2 and osteosarcoma: For example, long noncoding RNA CCAT1 was reported to act as an oncogene and promote chemoresistance in docetaxel-resistant lung adenocarcinoma cells [37]; lncRNA FENDRR may act as an inhibitory molecule of doxorubicin-resistance through down-regulating the expression of ABCB1 and ABCC1 genes in osteosarcoma cells [38]; long non-coding RNA LINC00161 has been showed to sensitize osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis [39].