As recently reviewed CREB overexpression and its constitutive activation was found in many solid tumors, including non-small cell lung carcinoma, glioblastoma, melanoma, mammary carcinoma, renal cell carcinoma and mesothelioma as well as in different hematopoietic malignancies [4, 12–18], leading to enhanced cell proliferation, reduced apoptosis, increased angiogenesis and migration rates. The gene discussed is CREB1; the disease is melanoma.