PLK4 and glioblastoma: Some functionally important proteins encoded by the 148 genes were identified, including polo like kinase 4 (PLK4), a tumor suppressor in GBM [7]; cyclin dependent kinase 6 (CDK6) [8]; PR/SET domain 10 (PRDM10) and myocyte enhancer factor 2C (MEF2C) (Supplementary Figure 3E).