Bcl-3 induction in the renal tissues of the UUO mice appeared in the early stage of renal fibrosis, similar to other fibrosis biomarkers, including Wfdc2, Snai1, Acta2, Col1α1, Tgfb1, P21 and Twist1. We observed that Bcl-3 and HE4 were highly expressed in the cytoplasm of liberal epithelial cells in the renal tissue of UUO mice. The gene discussed is TWIST1; the disease is renal fibrosis.