Although the data in the present study showed a significant correlation between serum Bcl-3 and serum HE4 protein levels, the evaluation of renal fibrosis in renal biopsies and the quantitative examination of serum Bcl-3 protein and HE4 protein in patients with CKD are required to confirm the value of Bcl-3 and its combination with HE4 in the detection of renal fibrosis. The gene discussed is WFDC2; the disease is chronic kidney disease.