Although the combination of serum Bcl-3 and HE4 was not better than Bcl-3 alone using western blotting in CKD patients, a quantitative measure of serum Bcl-3 and HE4 is needed to re-evaluate the value of the combination of Bcl-3 and HE4 in the detection of renal fibrosis in CKD patients. The gene discussed is BCL3; the disease is chronic kidney disease.