Hyperglycemia systematically impairs endogenous angiogenesis potential, as it induces aberrant expression of various angiogenesis factors, such as hypoxia-inducible factor 1 (HIF1)-α [9], vascular endothelial growth factor (VEGF) [10, 11] and platelet-derived growth factor (PDGF)-BB [12], resulted in the disruption of endogenous angiogenesis pathways. The gene discussed is HIF1A; the disease is Hyperglycemia.