Furthermore, although whether or not salidroside affects other angiogenic factors and/or cells involved in angiogenesis under hyperglycemia remains to be elucidated, our findings demonstrated, for the first time, that salidroside could restore the secretions of VEGF-A and PDGF-BB from skeletal muscle cells under hyperglycemia, which in turn lead to the activation of cell–cell communication between skeletal muscle cells and endothelial and/or smooth muscle cells. This evidence concerns the gene VEGFA and Hyperglycemia.