Together with our finding showing that hyperglycemia induces PHD3 accumulation in skeletal muscle cells, these facts indicate that the upregulation of skeletal muscle cells PHD3 under ischemic, hyperglycemic conditions, which then affects the endothelial and smooth muscle cells, might be one of the most crucial reasons for the impaired angiogenic potential in the diabetic patient. The gene discussed is EGLN3; the disease is Hyperglycemia.