When the conditioned medium used was collected from C2C12 cells overexpressing PHD3, the effects of the conditioned medium from salidroside-treated C2C12 cells on restoring the proliferation, migration and F-Actin polymerization potentials of MOVAS cells under hyperglycemia were cancelled (Figure 7A–7F). This evidence concerns the gene EGLN3 and Hyperglycemia.