To examine the role of PHD3 in promoting the proliferation and migration potentials of endothelial and smooth muscle cells induced by salidroside-treated skeletal muscle cells secretome under hyperglycemia, we collected conditioned media from C2C12 cells cultured under hyperglycemia; as well as conditioned media from C2C12 cells or C2C12 cells overexpressing PHD3, treated with salidroside and cultured under hyperglycemia. Here, EGLN3 is linked to Hyperglycemia.