In a validation set of 369 invasive breast cancers, high Shannon index for c-MYC copy number variation also correlated with adverse clinicopathologic features including high histologic grade, lymphovascular invasion, p53 overexpression, high Ki-67 proliferation index, and negative hormone receptor status (all p<0.001; Supplementary Table 1). The gene discussed is TP53; the disease is invasive breast carcinoma.