Kwei et al. divided the genetic alterations in breast cancer into three types: a “simple” type harboring only a few copy number alterations characteristic of the luminal A subtype, an “amplifier” type with focal high-level DNA amplification in the luminal B and HER2 subtypes, and, lastly, a “complex” type characteristic of the triple-negative subtype [37]. This evidence concerns the gene ERBB2 and breast carcinoma.